Levofloxacin Production Cost Reports

The report provides a detailed analysis essential for establishing a Levofloxacin manufacturing plant. It encompasses all critical aspects necessary for Levofloxacin production, including the cost of Levofloxacin production, Levofloxacin plant cost, Levofloxacin production costs, and the overall Levofloxacin manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Levofloxacin production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Levofloxacin, commercially known as Levaquin, is an antibacterial drug approved by the FDA and used in the treatment of a variety of bacterial infections such as tuberculosis, urinary tract infections, pneumonia, meningitis, anthrax, pelvic inflammatory disease, etc. It is a synthetic fluoroquinolone antibiotic that functions in inhibiting bacterial topoisomerase IV and DNA gyrase. It is an optically active S-(-)isomer of Ofloxacin and acts as a significant inhibitor of DNA synthesis. Levofloxacin is often referred to as “respiratory quinolone” due to its prominent activity against the gram-positive bacteria responsible for causing respiratory infections.

Several factors influence the procurement demand for Levofloxacin. The most prominent factor is its therapeutic application in pharmaceutical and medical industries as a potent antibacterial drug, utilized in the treatment of a broad range of bacterial infections like tuberculosis, pneumonia, urinary tract infections, meningitis, etc.

The increased prevalence of bacterial infections, especially tuberculosis and pneumonia worldwide, contributes to its growing market demand. The enhanced accessibility and affordability of the generic form of Levofloxacin make it a favorable option for patients, thereby boosting its market growth. Increased healthcare awareness amongst patients also contributes to its growing demand and significance. Additionally, surgical procedures have risks of certain bacterial infections, thereby increasing the demand for antibiotics such as Levofloxacin.

Overall, the industrial Levofloxacin procurement is influenced by its therapeutic applications in pharmaceutical and medical industries, a broad range of applications, increased prevalence of bacterial infections worldwide, cost-effectiveness, increased healthcare awareness, technological advancements, market dynamics, logistics and distribution, and regulatory approvals.

Raw Material for Levofloxacin Production

According to the Levofloxacin manufacturing plant project report, the key raw materials used in the production of Levofloxacin include (S)-(-)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid - N-methyl piperazine.

Manufacturing Process of Levofloxacin

The extensive Levofloxacin production cost report consists of the following major industrial manufacturing process:

• Production from (S)-(-)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid and N-methyl piperazine: The manufacturing process of Levofloxacin involves the reaction of (S)-(-)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid and N-methyl piperazine in the presence of DMSO at 80 °C to obtain Levofloxacin.

Levofloxacin, commercially known as Levaquin, is a white to light yellow crystal or crystalline powder having the molecular formula C18H20FN3O4 and a molecular weight of 361.4 g/mol. Its melting point is approximately in the range of 225-227 °C. It is sparingly soluble in water but freely soluble in glacial acetic acid and chloroform. It has a pKa value of 6.25. Levofloxacin is an antibiotic that inhibits the DNA gyrase and Topoisomerase IV activity. It is used in the treatment of a broad range of bacterial infections.