Loratadine Production Cost Reports

The report provides a detailed analysis essential for establishing a Loratadine manufacturing plant. It encompasses all critical aspects necessary for Loratadine production, including the cost of Loratadine production, Loratadine plant cost, Loratadine production costs, and the overall Loratadine manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Loratadine production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Loratadine is a member of the second-generation antihistaminic class of drugs. It functions as a cholinergic antagonist, an anti-allergic agent, an H1-receptor antagonist, and a geroprotector. It is used to treat a range of symptoms, including pruritus, watery eyes, runny noses, and seasonal allergy-related sneezing. It specifically blocks H1-receptors on immunological cells, gastrointestinal tract cells, vascular endothelial cells, and respiratory smooth muscle cells.

The procurement of Loratadine is influenced by its application in the pharmaceutical and medical industries as an antihistaminic medication to treat a range of allergic symptoms. The need for Loratadine is increasing as cases of allergic conditions are on the rise. It witnesses a significant demand from the aging population as they are more likely to be affected by allergic conditions. Loratadine is more suitable above the first-generation antihistaminics due to its absence of sedative and central nervous system side effects because it does not cross the blood brain barrier.

It is present in generic forms, which increases its affordability. Elderly patients and children over two years old can safely use Loratadine, thus increasing its demand. Overall, the industrial Loratadine procurement is influenced by its application in the pharmaceutical and medical industries as an antihistaminic medication to treat various allergic symptoms, the rising cases of allergy-related conditions, the aging population, fewer side effects, safe to use, along with cost-effectiveness, research and development, logistics and distribution, technological advancements, and regulatory approvals.

Raw Material for Loratadine Production

According to the Loratadine manufacturing plant project report, the key raw material used in the production of Loratadine include Benzyl halide.

Manufacturing Process of Loratadine

The extensive Loratadine production cost report consists of the following major industrial manufacturing process:

• Production from Benzyl halide: The manufacturing process of Loratadine has several important steps. In the first step, benzyl halide is subjected to cyanation in the presence of water-immiscible solvents to form phenyl acetonitrile. The phenyl acetonitrile is condensed with nicotinic ester to form ketonitrile. The ketonitrile undergoes hydrolyzation and decarboxylation in the presence of an acidic environment to form the respective ketone. The ketone is reduced, followed by its N-oxidation, cyclization, and hydrolysis to form picolinic acid. In the next step, the picolinic acid is cyclized to produce tricyclic ketone. The ketone is reacted with an organometallic compound having Mg to form carbinol. The carbinol is purified with a purifying agent and dehydrated with sulfuric acid at ambient temperature to give an N-methyl product (olefin). In the final step, the olefin is subjected to N-carbethoxylation to form Loratadine.

Loratadine, commercially known as Claritin, is a white to off-white powder, having the molecular formula C22H23ClN2O2 and a molecular weight of 382.9 g/mol. Its melting point is 134-136 °C. Its water solubility is 0.0134 mg/mL. Its log P value is 5.20 at pH 7.4. Its pKa value is 4.33. It easily dissolves in organic solvents such as acetone, alcohol, and chloroform and is insoluble in water. It is an H1 histaminic receptor antagonist used to treat various conditions related to allergy.