Lorazepam Production Cost Reports

The report provides a detailed analysis essential for establishing a Lorazepam manufacturing plant. It encompasses all critical aspects necessary for Lorazepam production, including the cost of Lorazepam production, Lorazepam plant cost, Lorazepam production costs, and the overall Lorazepam manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Lorazepam production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Lorazepam is a popular short-acting benzodiazepine used as a sedative and anxiolytic for treating seizures, severe anxiety, and panic disorders. The US Food and Drug Administration (FDA) has approved Lorazepam for the short-term treatment of anxiety symptoms related to anxiety disorders, anxiety-related insomnia, adult anesthesia premedication to induce sedation or amnesia or relieve anxiety, and the management of status epilepticus.

The procurement of Lorazepam is influenced by its application in the pharmaceutical and medical industries as a sedative and anxiolytic to treat various symptoms related to anxiety disorder. The need for Lorazepam is increasing as cases of anxiety disorders are on the rise. It witnesses a significant demand from the aging population as they are more likely to be affected by anxiety and sleep disorders. Lorazepam is used off-label for various conditions such as sleeplessness, panic disorder, delirium, alcohol withdrawal syndrome, vertigo, chemotherapy-associated anticipatory nausea, and vomiting (adjunct or breakthrough), delirium, and psychogenic catatonia, thus increasing its demand.

In several clinical settings, Lorazepam is utilized in comparison to other benzodiazepines. Clinicians use it in acute, short-term, and long-term contexts, ranging in specialization and practice level. Because it acts quickly (in 1-3 minutes when administered intravenously), it is used in hospital settings. Therefore, the industrial Lorazepam procurement is influenced by its application in the pharmaceutical and medical industries as a sedative and anxiolytic, the rising cases of anxiety and sleep disorders, the aging population, its wide range of applications, its off-label uses, quick onset of action, clinical uses, fewer side effects, along with cost-effectiveness, increasing awareness among individuals regarding mental health, research and development, and regulatory approvals.

Raw Material for Lorazepam Production

According to the Lorazepam manufacturing plant project report, the key raw material used in the production of Lorazepam includes 2-amino-2′,5-dichlorobenzophenone.

Manufacturing Process of Lorazepam

The extensive Lorazepam production cost report consists of the following major industrial manufacturing process:

• Production from 2-amino-2′,5-dichlorobenzophenone: The manufacturing process of Lorazepam starts with the N-acylation of 2-amino-2′,5-dichlorobenzophenone in the presence of chloroacetyl chloride and toluene to form a chloro intermediate. The chloro intermediate is subjected to cyclization using hexamine and NH4OAc to form delorazepam. In the next step, delorazepam is oxidized with m-chloroperbenzoic acid to form an N-oxide intermediate. The delorazepam N-oxide intermediate is treated with acetic anhydride, and to this mixture, NH4OH and ethanol are added, which finally gives Lorazepam.

Lorazepam, commercially known as Ativan, is a white powder having the molecular formula C15H10Cl2N2O2 and a molecular weight of 321.2 g/mol. It has a boiling point of 533.8 °C at 760 mm Hg and a melting point in the range of 192-194 °C. It has a log P value of 2.39. The value of its dissociation constant, pKa, is 13. It is highly soluble in water with a solubility of 80 mg/L. It also dissolves in organic solvents such as ethanol and methanol. It is a member of the class of medications called benzodiazepines, used to treat a variety of symptoms related to anxiety disorders.