Losartan Potassium (Cozaar) Production Cost Reports

The report provides a detailed analysis essential for establishing a Losartan Potassium (Cozaar) manufacturing plant. It encompasses all critical aspects necessary for Losartan Potassium (Cozaar) production, including the cost of Losartan Potassium production, Losartan Potassium plant cost, Losartan Potassium (Cozaar) production costs, and the overall Losartan Potassium manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Losartan Potassium production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Losartan Potassium is a potassium salt of Losartan. It is an important angiotensin receptor blocker (ARB) used to treat hypertension (high blood pressure) and heart failure. It functions by inhibiting the action of angiotensin II, which is a potent vasoconstrictor, thereby relaxing the blood vessels, improving the blood flow, and reducing the elevated blood pressure. It is utilized for managing heart failure.

Losartan Potassium can help preserve kidney function in patients with diabetic neuropathy by decreasing the excessive protein levels in the kidney. It can also be used in patients with type-2 diabetes mellitus to prevent complications in the kidney by lowering the blood pressure and preventing protein loss in urine.

It also functions to lower the risk of stroke in adults with high blood pressure and left ventricular hypertrophy. It can also be combined with other antihypertensives, such as diuretics, to enhance blood pressure management. It also has its use in Marfan syndrome, which is a genetic condition affecting the proteins responsible for maintaining healthy connective tissue. Additionally, it functions as a corrosion inhibitor for steel in acidic conditions.

Several factors influence the industrial procurement of Losartan Potassium. The most important factor is its therapeutic applications in pharmaceutical and medical industries as an angiotensin receptor blocker used in the treatment of hypertension, heart failure, left ventricular hypertrophy, and stroke. Its efficacy in conditions such as diabetic neuropathy and use in Marfan syndrome boosts its market value. Its chemical property to inhibit corrosion protects the metal surfaces, thus making it useful in chemical industries. The growing incidence rate of hypertension, especially in the aging population, is enhancing the global demand for Losartan Potassium. Losartan Potassium provides a more affordable treatment alternative, being a generic drug, which contributes to its increasing demand.

Improvements in formulation and manufacturing techniques are boosting the efficiency and quality of Losartan Potassium production, thereby supporting its market expansion. Continuous research and development to discover new applications for Losartan Potassium or refine its formulations can generate further market opportunities. Conclusively, the industrial Losartan Potassium procurement is influenced by its therapeutic applications in the pharmaceutical and medical industries, use in various indications, corrosion inhibitor in the chemical industry, cost-effectiveness, market dynamics, logistics and distribution, research and development, technological advancements, and regulatory approvals.

Raw Material for Losartan Potassium (Cozaar) Production

According to the Losartan Potassium manufacturing plant project report, the key raw materials used in the production of Losartan Potassium include 2-butyl-4-chloro-5-formyl imidazole - 2-cyano-4-bromomethyl biphenyl.

Manufacturing Process of Losartan Potassium (Cozaar)

The extensive Losartan Potassium production cost report consists of the following major industrial manufacturing process:

• Production from 2-butyl-4-chloro-5-formyl imidazole and 2-cyano-4-bromomethyl biphenyl.: The manufacturing process for Losartan Potassium involves several key steps. Firstly, 2-butyl-4-chloro-5-formyl imidazole is combined with 2-cyano-4-bromomethyl biphenyl in the presence of a solvent (like toluene), to form an intermediate compound. The resulting intermediate is then reduced using sodium borohydroxide, followed by the formation of a tetrazole ring (an important part of Losartan Potassium) through a reaction with sodium azide and an amine salt. The final step involves converting the product into Losartan Potassium by adding potassium hydroxide in an alcohol medium.

Losartan Potassium (Cozaar) is a white to off-white crystalline powder having the molecular formula C22H25ClN6O2K and a molecular weight of 461.0 g/mol. It is sparingly soluble in water but soluble in organic solvents such as ethanol and methanol. Its IUPAC name is potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol. It is stable within a pH range of 4 to 7. It is commonly known as Cozaar. It is usually available as Losartan Potassium oral tablets. Losartan Potassium is an angiotensin II receptor blocker used in the treatment of hypertension and heart failure.