Mianserin Production Cost Reports

The report provides a detailed analysis essential for establishing a Mianserin manufacturing plant. It encompasses all critical aspects necessary for Mianserin production, including the cost of Mianserin production, Mianserin plant cost, Mianserin production costs, and the overall Mianserin manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Mianserin production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Mianserin is a medication that is widely used in the medical and pharmaceutical industries as an antidepressant. The compound is used as a drug for the treatment of depression. Moreover, it is also utilized as an oral antidepressant for the treatment of anxiety and other major depressive disorders. Additionally, it is also employed as a therapy for managing insomnia or agitation in patients with depression.

Its application as an oral drug for the treatment of anxiety and depressive disorders notably drives its market and contributes to its demand in the pharmaceutical industry. Mianserin tablets are prescribed for the management of depressive disease symptoms due to their hypnotic effects, which significantly boosts its market growth. Furthermore, several factors influence industrial Mianserin procurement, such as the availability of raw materials (2-benzylaniline, etc.), cost and pricing, compliance with pharmaceutical regulations, quality standards, technological advancements, environmental considerations, sustainability practices, distribution (including trading and shipping), logistics, safety standards, etc.

Raw Material for Mianserin Production

According to the Mianserin manufacturing plant project report, the major raw material for Mianserin production includes 2-Benzylaniline- Pyridine-Chloroacetyl Chloride.

Manufacturing Process of Mianserin

The extensive Mianserin production cost report consists of the following industrial manufacturing processes:

1. Production from 2-Benzylaniline: This method of production is initiated by the reaction of 2-benzylaniline dissolved in benzene with pyridine and chloroacetyl chloride at 10°–15°C to give N-chloroacetyl-2-benzylaniline. Further, the obtained N-chloroacetyl-2-benzylaniline is heated with phosphorus oxychloride and polyphosphoric acid at 120°C to form 6-chloromethyl-morphanthridine, followed by its reaction with methylamine in benzene for 20 hours to synthesize 6-methylaminomethyl-morphanthridine. Then, the obtained product is treated with lithium aluminum hydride in ether, followed by the addition of water to give 5,6-dihydro-6-methylaminomethyl-morphanthridine. Then, the obtained compound is heated with diethyloxalate at 100°–180°C to form 1,2-diketo-3(N)-methyl-2,3,4,4a-tetrahydro-1H-pyrazino-[1,2-f]-morphanthridine, followed by reduction with diborane, which results in the formation of Mianserin as the final product.

Mianserin is widely recognized as a tetracyclic compound having antidepressant properties. The molecular formula of the compound is C18H20N2, and its molar mass is 264.4 g/mol. Moreover, its exact mode of therapeutic action is unknown, although the drug seems to block some types of serotonin receptors, histamine H1, and alpha-adrenergic receptors. It could result in dizziness and sleepiness. Other common side effects of this drug include weight gain, dry mouth, headaches, etc.

Additionally, the boiling point of the compound is 397.6°C, and its density is 1.0092gm/cm3. It exists in the form of a powder that is completely soluble in DMSO. The compound is stored at the temperature of -20°C, and its pka value is 7.5.