Milnacipran Hydrochloride Production Cost Reports

The report provides a detailed analysis essential for establishing a Milnacipran Hydrochloride manufacturing plant. It encompasses all critical aspects necessary for Milnacipran Hydrochloride production, including the cost of Milnacipran Hydrochloride production, Milnacipran Hydrochloride plant cost, Milnacipran Hydrochloride production costs, and the overall Milnacipran Hydrochloride manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Milnacipran Hydrochloride production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Milnacipran Hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) that finds major applications in the medical industry. It serves as an FDA-approved drug utilized for the treatment of fibromyalgia, which is a long-lasting condition that causes pain, tenderness, muscle stiffness, tiredness, etc. Moreover, it also finds its application as a medicine for the treatment of major depressive disorder (MDD), anxiety, and other depressive disorders.

The demand for Milnacipran Hydrochloride is majorly driven by its application for the treatment of fibromyalgia-related pain in adults, fueling its growth in the medical and pharmaceutical industries. Its employment as an antidepressant for the short-term treatment of major depressive disorder (MDD) in adults significantly promotes its demand in the medical industry. Moreover, its usage as a medication for the treatment of pain associated with fibromyalgia in patients aged 18 years and older further enhances its demand in the healthcare and pharmaceutical industries.

Furthermore, several factors, such as the availability of raw materials (Lactone, etc.), cost and pricing, compliance with healthcare regulations, maintaining quality standards, technological advancements, strong supplier relationships, sustainability practices, distribution (including trading and shipping), and logistics majorly influence industrial Milnacipran hydrochloride procurement across the globe.

Raw Material for Milnacipran Hydrochloride Production

According to the Milnacipran Hydrochloride manufacturing plant project report, the major raw materials for Milnacipran Hydrochloride production includes Lactone-Toluene-Ethanolamine-Hydrochloric Acid.

Manufacturing Process of Milnacipran Hydrochloride

The extensive Milnacipran Hydrochloride production cost report consists of the following industrial manufacturing process:

• Production from Lactone: This method of production involves cyclopropanation reaction and lactonization sequence to synthesize optically active lactone by using toluene as a solvent to obtain levomilnacipran. The most active enantiomer of the racemate Milnacipran is called levomilnacipran. The process of producing milnacipran hydrochloride is initiated by the conversion of lactone to amide alcohol through lactone ring opening by using diethylamine. Further, the primary alcohol obtained is converted to an alkyl chloride intermediate, followed by substitution with potassium phthalimide to give phthalimido amide in just 3 steps. Then, the obtained phthalimide intermediate is deprotected with ethanolamine to obtain levomilnacipran, which is further treated with a mixture of HCl, isopropanol, isopropyl acetate in toluene to obtain Milnacipran Hydrochloride as the final product.

Milnacipran Hydrochloride is a compound that belongs to the family of acetamides. The molecular formula of the compound is C15H23ClN2O, and its molecular weight is 282.81 g/mol. The compound is also known as Milnacipran HCl, Dalcipran, or Toledomin. Moreover, the compound serves as a drug for the treatment of depression. The solubility of the compound in water is around 1.23 mg/mL, and its dissociation constant value is pKa (Strongest Basic) = 9.83. Additionally, the IUPAC name of the compound is 2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide hydrochloride. This drug is mainly marketed under the trade name Ixel, Savella, Dalcipran, or Toledomin, which is available in the form of tablets.