Niacinamide Production Cost Reports

The report provides a detailed analysis essential for establishing a Niacinamide manufacturing plant. It encompasses all critical aspects necessary for Niacinamide production, including the cost of Niacinamide production, Niacinamide plant cost, Niacinamide production costs, and the overall Niacinamide manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Niacinamide production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Niacinamide is an active form of Vitamin B3 that has various benefits, like helping build proteins in the skin and sealing moisture. It also has other advantages like boosting skin immunity, helping skin create a lipid barrier, reducing signs of redness and blotchiness, minimizing pore size, regulating oil levels, preventing sun damage, treating hyperpigmentation, reducing fine lines and wrinkles, offering protection against oxidative stress, and treats acne.

In the medical segment, Niacinamide works as a chemo- and radio-sensitizing agent as it enhances tumor blood flow, which helps lower tumor hypoxia. It inhibits poly(ADP-ribose) polymerases, enzymes involved in reconnecting DNA strand breaks that occur due to radiation or chemotherapy. Furthermore, its consumption can help prevent skin-related issues like acne or eczema, as well as diseases caused by a deficiency of niacin and pellagra.

The market for Niacinamide is driven by its usage in skincare and health supplements for skin concerns such as acne, hyperpigmentation, and aging, which elevates its demand in the skincare and cosmetics industries. The rising cases of skin diseases globally amplifies its market demand. The growing cosmetics industry also boosts its market growth. Its function as a chemo- and radio-sensitizing agent fuels its market value in the medical industry.

The awareness among consumers towards the use of natural and multifunctional ingredients in their skincare routines as well as the rising focus on skin health, further contribute to the market expansion for Niacinamide. Also, industrial Niacinamide procurement is influenced by various innovations and product formulations in sectors such as the beauty and personal care industry.

Raw Material for Niacinamide Production

According to the Niacinamide manufacturing plant project report, the key raw materials used in the production of Niacinamide include nicotinonitrile; nicotinic acid-ammonia; 2-methyl-1,5-pentanediamine.

Manufacturing Process of Niacinamide

The extensive Niacinamide production cost report consists of the following major industrial manufacturing processes:

• Production via hydrolysis: The manufacturing process of Niacinamide occurs from nicotinonitrile via the hydrolysis process. In this process, nicotinonitrile is hydrolyzed in the presence of an enzymatic catalyst, such as nitrile hydratase, to produce Niacinamide.
• Production from nicotinic acid and ammonia: The manufacturing process of Niacinamide occurs from nicotinic acid and ammonia. In this process, melted nicotinic acid is reacted with ammonia gas using ammonium salt as a catalyst to produce Niacinamide, followed by further purification.
• Production from 2-Methyl-1,5-Pentanediamine: The production process of Niacinamide occurs from 2-methyl-1,5-pentanediamine(MPDA). The process starts with the vaporization of MPDA to form 3-methylpiperidine (MPI) via deamination, resulting in a ring closure in the presence of the zeolite catalyst. The methyl piperidine undergoes dehydrogenation to give 3-picoline (PIC) over a Pd-SiO2/Al2O3 catalyst. The picoline is subjected to an exothermic ammoxidation to form 3-cyanopyridine (CNP). Finally, CNP is converted to Niacinamide via an enzymatic hydrolysis process in the presence of a biocatalyst (nitrile hydratase.

Niacinamide or nicotinamide is an active form of vitamin B3, which is among the eight B vitamins required by the body. It's part of the coenzyme nicotinamide adenine dinucleotide (NAD). The agent is a pyridine carboxamide, which is pyridine, where a carboxamide group substitutes the hydrogen at position 3. It functions as an NAD(+) ADP-ribosyltransferase inhibitor, a cofactor, a neuroprotective agent, a metabolite, an antioxidant, an EC 3.5.1.98 (histone deacetylase) inhibitor, a Saccharomyces cerevisiae metabolite, an anti-inflammatory agent, an Escherichia coli metabolite, a Sir2 inhibitor, a mouse metabolite, a human urinary metabolite and a geroprotector. It can be found in several foods like fish, meat, eggs, milk, cereals, and green vegetables. Niacinamide is available in the state of a white powder that has no odor and a bitter taste. It has a molecular weight of 122.12 g/mol. It has a melting point in the range of 264 to 268 °F or 129 to 131°C.