Olaparib Production Cost Reports

The report provides a detailed analysis essential for establishing an Olaparib manufacturing plant. It encompasses all critical aspects necessary for Olaparib production, including the cost of Olaparib production, Olaparib plant cost, Olaparib production costs, and the overall Olaparib manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating an Olaparib production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Olaparib is an FDA-approved chemical compound that is employed as a drug in anti-cancer therapy. It is utilized for the treatment of advanced ovarian cancer. Moreover, it also finds its application for the treatment of BRCA1/BRCA2 associated tumors, including ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer. It is often used for maintenance therapy for patients of advanced epithelial ovarian cancer who exhibit response and are subject to recurrence.

The demand for Olaparib is primarily driven by its application as an antineoplastic agent for the treatment of various cancers, including ovarian, breast, and prostate cancers, which significantly fuels its demand in the medical industry. Moreover, its employment in the treatment of cancer-based on individual genetic mutations further contributes to its demand in the healthcare industry and enhances its market growth. Furthermore, its medical applications, the availability and cost of raw materials like dimethyl phosphite etc., regulatory compliance, maintaining quality standards, supplier relationships, efficient distribution, and sustainability practices are major factors that globally influence industrial Olaparib procurement.

Raw Material for Olaparib Production

According to the Olaparib manufacturing plant project report, the major raw materials for Olaparib production include Dimethyl Phosphite and 2-Carboxybenzaldehyde.

Manufacturing Process of Olaparib

The extensive Olaparib production cost report consists of the following industrial manufacturing process:

• Production via Chemical Synthesis: This method of production is initiated by the reaction of dimethyl phosphite and 2-carboxybenzaldehyde to form corresponding phosphonate ester as an intermediate. Further, 4-fluoro-3-cyanobenzaldehyde is added to the obtained phosphonate ester intermediate in the presence of triethylamine to produce olefins in 96% yield as a 1:1 mixture of E/Z isomers, followed by a one-pot, three-step sequence to synthesize dihydrophthalazinyl acid. Further, the obtained compound undergoes a coupling reaction with Bocpiperazine in the presence of (HBTU, DIPEA, and DMA), followed by removing the carbamate by using HCl/EtOH to form piperazine. Then, the obtained piperazine is treated with cyclopropane carbonyl chloride and triethylamine, which results in the formation of Olaparib as the final product.

Olaparib belongs to the class of N-acylpiperazines, and it serves as a drug for the treatment of advanced ovarian cancer. Moreover, the molecular formula of the compound is C24H23FN4O3, and its trade name is 434.5 g/mol. The density of the compound is 1.43gm/cm3, and it is soluble in ethanol and DMSO.  The compound exists as an off-white solid that is generally stored at the temperature of -20°C. Additionally, its value of dissociation constant (pka) is 12.07.