Phenobarbital Production Cost Reports

The report provides a detailed analysis essential for establishing a phenobarbital manufacturing plant. It encompasses all critical aspects necessary for phenobarbital production, including the cost of phenobarbital production, phenobarbital plant cost, phenobarbital production costs, and the overall phenobarbital manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a phenobarbital production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Phenobarbital is a type of medication that finds a wide range of applications in the medical and pharmaceutical industries. It is widely utilized as an antiepileptic drug for the treatment of both minor and major epileptic attacks, spastic paralysis, and chorea. Moreover, it often finds its application as a pre-anesthetic to regulate agitation in emergency conditions. Additionally, it is also employed as a sedative to induce drowsiness and relieve anxiety before certain surgical procedures.

The market for phenobarbital is majorly driven by its efficacy in anti-seizure management, treatment for status epilepticus, and other versatile applications, which remarkably propels its demand in the medical and healthcare industries. Moreover, its utilization as an anticonvulsant for the treatment of seizures in patients with epilepsy and managing alcohol withdrawal effectively enhances its demand in the medical and pharmaceutical industries. Additionally, its application for the treatment of insomnia further promotes its market growth. Furthermore, several factors influence industrial phenobarbital procurement, such as the cost and availability of raw materials (phenylmalonic acid, ethyl bromide, etc.), cost and pricing, compliance with pharmaceutical regulations, quality standards, technological advancements, environmental considerations, sustainability practices, distribution (including trading and shipping), logistics, safety standards, etc.

Raw Material for Phenobarbital Production

According to the Phenobarbital manufacturing plant project report, the major raw materials for Phenobarbital production include Phenylmalonic Acid-Ethyl Bromide-Urea; Malonic Esters-Malonic Amides/Cyanoacetic Esters-Urea.

Manufacturing Process of Phenobarbital

The extensive Phenobarbital production cost report consists of the following industrial manufacturing processes:

1. Production from Phenylmalonic Acid: This process is initiated by the reaction of phenylmalonic acid with ethyl bromide to form an intermediate, ethyl phenylmalonate, through an esterification reaction. The intermediate obtained further undergoes dehydrobromination to remove bromine, followed by decarboxylation to produce a β-keto ester. Further, β-keto ester is reacted with urea in a cyclization reaction to produce phenobarbital.
2. Production via Condensation: This method of production involves the synthesis of phenobarbital through the classical condensation of substituted malonic esters, malonic amides, or cyanoacetic esters with urea or dicyanodiamide to produce imino- or cyanobarbiturate. This product obtained is further hydrolyzed to synthesize phenobarbital (5,5-disubstituted barbituric acid).

Phenobarbital is a member of the group of barbiturates and is considered superior to other barbiturates due to its potential anticonvulsant effects. The IUPAC name of the compound is 5-ethyl-5-phenyl-1,3-diazinane-2,4,6-trione. The compound is often recognized by its other names, phenobarbital, phenobarbitone, or phenobarbital. The molecular formula of the compound is C12H12N2O3, and its molar mass is 232.23 g/mol. Moreover, the compound appears as a colorless or white crystalline powder that is slightly bitter. The melting point of the compound is 174°C, and its flash point is 345 °F. This compound is very sensitive to moisture and air. It produces toxic fumes of nitrogen oxides when it is decomposed in the presence of heat.