Prednisolone Acetate Production Cost Reports

The report provides a detailed analysis essential for establishing a Prednisolone Acetate manufacturing plant. It encompasses all critical aspects necessary for Prednisolone Acetate production, including the cost of Prednisolone Acetate production, Prednisolone Acetate plant cost, Prednisolone Acetate production costs, and the overall Prednisolone Acetate manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Prednisolone Acetate production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Prednisolone Acetate is an FDA-approved synthetic corticosteroid hormone having immunomodulating properties. It is widely used to treat conditions such as rheumatoid arthritis, rheumatic fever, lupus erythematosus, scleroderma, Dermatomyositis, acute lymphoblastic leukemia, and various other immune system disorders. Moreover, it also finds its application in the treatment of a variety of inflammatory, endocrine, and immune conditions. Additionally, it is often utilized in endocrine or neoplastic conditions as well as in organ transplant patients.

The market for Prednisolone Acetate is mainly led by its industrial application as a potent immunosuppressant to help relieve severe allergic reactions, which significantly boosts its demand in the medical and pharmaceutical industry. Its huge application as a medicine for the treatment of rheumatoid arthritis, rheumatic fever, lupus erythematosus, scleroderma, dermatomyositis, and other inflammatory conditions further enhances its demand in the medical and healthcare industries. Moreover, its employment in the treatment of immune system disorders and certain neoplastic conditions effectively fuels its market growth.

Additionally, several factors impact industrial Prednisolone Acetate procurement, such as the availability of raw materials (Prednisolone., etc.), cost, regulatory compliance, and maintenance of quality standards. Additionally, technological advancements, supplier relationships, sustainability practices, distribution (including trading and shipping), logistics, safety standards, etc., are also some major factors that play a huge role in shaping procurement techniques.

Raw Material for Prednisolone Acetate Production

According to the Prednisolone Acetate manufacturing plant project report, the major raw materials for Prednisolone Acetate production include Acetic Anhydride- Prednisolone.

Manufacturing Process of Prednisolone Acetate

The extensive Prednisolone Acetate production cost report consists of the following industrial manufacturing process:

• Production from Prednisolone: This method of production is initiated by the addition of 3 ml acetic anhydride to a solution of 0.85 gram of 1,4-pregnadiene-11β,17α,21-triol-3,20-dione (prednisolone) in 5 ml of pyridine. Further, the reaction mixture is diluted with ice water after leaving it at room temperature overnight to form a precipitate. Then, the obtained precipitate is filtered from the mixture and recrystallized from acetone-hexane, which results in the formation of 1,4-pregnadiene-11β,17α,21-triol-3,20-dione 21-acetate or prednisolone acetate.

Prednisolone Acetate is the acetate salt form of a synthetic glucocorticoid, prednisolone. It serves as a compound with anti-inflammatory properties. The molecular formula of the compound is C23H30O6, and its molar mass is 402.5 g/mol. Moreover, the compound is also known as Prednisolone 21-acetate or Omnipred. The compound appears in the form of a white to off-white solid that does not dissolve in water but is slightly soluble in ethanol and methylene chloride.

Additionally, the density of the compound is around 1.28±0.1 g/cm3, and its flash point is 198.4°C.  Its melting point and boiling point range between 240-244°C and 579.8±50.0 °C, respectively. The compound is generally stable, but it shows incompatibility with strong oxidizing agents. This drug is mainly marketed under the trade name Econopred (Alcon).