Ramipril Production Cost Reports

The report provides a detailed analysis essential for establishing a Ramipril manufacturing plant. It encompasses all critical aspects necessary for Ramipril production, including the cost of Ramipril production, Ramipril plant cost, Ramipril production costs, and the overall Ramipril manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Ramipril production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Ramipril is a prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It finds huge applications in the treatment of high blood pressure and congestive heart failure. It is also utilized for improving survival after a heart attack. Additionally, it is also employed as a vasoconstrictor in the treatment and prevention of myocardial infarction, diabetic nephropathy, and stroke in individuals at high risk of cardiovascular events.

The market for Ramipril is primarily driven due to its key role as an antihypertensive agent in the treatment of high blood pressure or hypertension, which significantly fuels its demand in the pharmaceutical industry. Moreover, its utilization in the treatment and prevention of congestive heart failure, strokes, and renal and retinal complications in diabetes further enhances its demand in the medical, healthcare, and pharmaceutical industries. Furthermore, several factors, such as the availability of raw materials (salt of bicyclic amino ester, etc.), cost and pricing, compliance with medical regulations, and quality standards, significantly influence industrial Ramipril procurement globally.

Raw Material for Ramipril Production

According to the Ramipril manufacturing plant project report, the major raw materials for Ramipril production include Salt of Bicyclic Amino Ester- N-(l-S carboethoxy)-3-phenyl-propyl-L-alanine.

Manufacturing Process of Ramipril

The extensive Ramipril production cost report consists of the following industrial manufacturing process:

• Production via Coupling Reaction: This method of production involves the DCC-HOBt mediated coupling of intermediates, which results in the formation of Ramipril. The process is initiated by reacting an acid addition salt of bicyclic amino ester (benzyl (S,S,S)-2-azabicyclo[3.3.0]octane-3-carboxylate) with N-(l-S carboethoxy)-3-phenyl-propyl-L-alanine in the presence of dicyclohexylcarbodimide (DCC) and 1 -hydroxybenzotriazole (HOBt) in a suitable solvent, followed by the removal of benzyl ester to synthesize optically pure Ramipril as the final product.

Ramipril belongs to the class of medicines that inhibit angiotensin-converting enzyme (ACE). The molecular formula of the compound is C23H32N2O5, and its molar mass is 416.5 g/mol. The compound is a drug that finds huge applications in the medical industry. It is mainly sold under trade names including Ramace, Altace, and Tritace. Moreover, the boiling point of the compound is 616.2, and its melting point ranges between 106-108°C. The density of the compound is 1.200  g/cm3, and it is slightly soluble in methanol and DMSO. Additionally, the compound exists in the form of a white or off-white crystalline powder that is stored at +4°C.