Rifabutin Production Cost Reports

The report provides a detailed analysis essential for establishing a Rifabutin manufacturing plant. It encompasses all critical aspects necessary for Rifabutin production, including the cost of Rifabutin production, Rifabutin plant cost, Rifabutin production costs, and the overall Rifabutin manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Rifabutin production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Rifabutin is an antibiotic that finds huge applications in the treatment of bacterial infections. It is extensively used for the treatment of tuberculosis (TB), especially in patients who are also infected with HIV. Moreover, it also finds its application in the prevention of disseminated Mycobacterium avium complex (MAC) infection in HIV-positive patients. Additionally, it is also employed in combination with other drugs as a treatment and prevention therapy for non-tuberculous mycobacterial diseases.

The demand for Rifabutin is largely led by its role as a broad-spectrum antibiotic widely used as a treatment against tuberculosis (TB), which significantly boosts its demand in the healthcare and pharmaceutical industries. Moreover, its application as an oral drug for the prevention and treatment of disseminated MAC in both HIV-infected and non-HIV-infected individuals further accelerates its market growth. Additionally, the availability of raw materials (sodium azide, etc.), cost and pricing, compliance with medical regulations, adherence to quality standards, technological advancements, distribution (including trading and shipping), logistics, safety standards, etc., are some of the major factors that largely influence industrial Rifabutin procurement.

Raw Material for Rifabutin Production

According to the Rifabutin manufacturing plant project report, the major raw materials for Rifabutin production include RIFA-001(intermediate)-Sodium Azide- Ammonium Thiosulfate-Ammonia.

Manufacturing Process of Rifabutin

The extensive Rifabutin production cost report consists of the following industrial manufacturing process:

1. Production via Chemical Synthesis: This method of production involves the transformation of the carbonyl group at the α position of RIFA-001 as the starting step of the synthesis. The process is initiated by the reaction of sodium azide with RIFA-001, which replaces the carbonyl group with an azide group. Further, the obtained compound undergoes reduction with ammonium thiosulfate, which results in the conversion of the azide group into an amino group and forming RIFA-002. Then, the ketone carbonyl group of the compound RIFA-002 is converted to an imine to synthesize RIFA-003 on reaction with ammonia. Further, a ring-closing reaction occurs by reacting RIFA-003 with RIFA-004 in the presence of zinc powder, which results in the formation of Rifabutin as the final product.

Rifabutin is an antibacterial derivative of rifamycin, and it exists in the form of reddish-brown powder. The molecular formula of the compound is C46H62N4O11, and its molecular weight is 847.0 g/mol. Moreover, the compound serves as a drug that is largely marketed under the trade name Mycobutin. The compound is administered orally. Additionally, the melting point of the compound is 169-171°C, and its boiling point is 969.6°C. It has a density of 1.33 g/cm3, and it is stored in a freezer at -20°C, in a dark place and inert atmosphere. The compound is hygroscopic and sensitive to light, and its solubility in water is 0.19g/L.