Rifampicin Production Cost Reports

The report provides a detailed analysis essential for establishing a Rifampicin manufacturing plant. It encompasses all critical aspects necessary for Rifampicin production, including the cost of Rifampicin production, Rifampicin plant cost, Rifampicin production costs, and the overall Rifampicin manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Rifampicin production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Rifampicin is an FDA-approved antibacterial prescription medicine that finds major applications in the pharmaceutical industry. It is widely used as an antibiotic for the treatment of tuberculosis, brucellosis, and other infectious diseases. Moreover, it also finds its application in the treatment of leprosy and certain other bacterial infections. Additionally, it is also used to relieve the pruritus of primary biliary cirrhosis. 
The demand for Rifampicin is majorly driven due to its application as a semisynthetic antibiotic used to treat tuberculosis and tuberculosis-related mycobacterial infections, which significantly promotes its market growth.

Moreover, its employment as an antipruritic agent for the treatment of autoimmune cholestatic liver disease and primary biliary cirrhosis (PBC) further fuels its demand in the healthcare and pharmaceutical industries. Additionally, procurement practices are defined on the basis of several factors, including the cost and the availability of raw materials (rifamycin, etc), regulatory compliance, and environmental guidelines. Moreover, technological advancements in the production process, supplier reliability, sustainability practices, and efficient logistics largely impact industrial Rifampicin procurement globally.

Raw Material for Rifampicin Production

According to the Rifampicin manufacturing plant project report, the major raw materials for Rifampicin production include Rifamycin-Formaldehyde-Pyrrolidine-1-amino-4-methylpiperazine.

Manufacturing Process of Rifampicin

The extensive Rifampicin production cost report consists of the following industrial manufacturing process:

1. Production from Rifamycin: This method of production is initiated by oxidizing the solution of rifamycin to a new derivative of rifamycin S, along with the formation of an intermediate rifamycin O, followed by reduction of the quinone structure of this product with hydrogen in the presence of a palladium on carbon catalyst to form rifamycin SV. Further, the obtained rifamycin SV undergoes aminomethylation by using a mixture of formaldehyde and pyrrolidine to give 3-pyrrolidi[1]nomethylrifamicin SV. Then, the obtained compound is further oxidized with lead tetraacetate to an enamine, followed by hydrolysis with an aqueous solution of ascorbic acid to obtain 3-formylrifamicin SV. As the last step, the obtained compound is then reacted with 1-amino-4-methylpiperazine, which results in the formation of Rifampicin as the final product.

Rifampicin is a semisynthetic antibiotic that belongs to the class of rifamycins. The molar mass of the compound is 822.9 g/mol, and its molecular formula is C43H58N4O12. Moreover, the melting point of the compound is 183°C, and its boiling point is 761.02°C. The density of the compound is 1.1782 g/cm3, and the value of its dissociation constant is 1.7, 7.9 (at 25). Additionally, the compound appears as a red-to-orange crystalline solid that is stored at a temperature range of 2-8°C. The compound is hygroscopic, light-sensitive, and readily soluble in water, DMSO, methanol, ethyl acetate, chloroform, methanol, and tetrahydrofuran. The compound is also known as Rifampin.