Tamoxifen Production Cost Reports

The report provides a detailed analysis essential for establishing a Tamoxifen manufacturing plant. It encompasses all critical aspects necessary for Tamoxifen production, including the cost of Tamoxifen production, Tamoxifen plant cost, Tamoxifen production costs, and the overall Tamoxifen manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Tamoxifen production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Tamoxifen is an FDA-approved drug that is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). It serves as an estrogen antagonist used for high levels of estrogen in breast cancer patients. Moreover, it also finds its application as a therapy after surgery for breast cancer metastasis. Additionally, it is also employed as a medicine for the treatment of ovarian cancer, endometrial cancer, and endometriosis.

The market for Tamoxifen is primarily driven by its utilization as a nonsteroidal antiestrogen for the treatment of breast cancer, which significantly boosts its demand in the healthcare and pharmaceutical industries. Moreover, its utilization as a preventive treatment in women at high risk of developing breast cancer, such as in people with specific genetic mutations or those with a family history, further promotes its market growth. Additionally, variations in its cost and the availability of raw materials (α -Ethyldesoxybenzoin, etc.), regulatory compliance, and pharmaceutical regulations play an important role in defining procurement guidelines. Moreover, advancements in the production process, supplier reliability, sustainability practices, and efficient logistics largely impact industrial tamoxifen procurement globally.

Raw Material for Tamoxifen Production

According to the Tamoxifen manufacturing plant project report, the major raw materials for Tamoxifen production include α-Ethyldesoxybenzoin-4-Methoxyphenylmagnesium Bromide.

Manufacturing Process of Tamoxifen

The extensive Tamoxifen production cost report consists of the following industrial manufacturing process:

1. Production via Condensation: This method of production is initiated by the chemical reaction of α-Ethyldesoxybenzoin with 4-methoxyphenylmagnesium bromide to form the corresponding carbinol. Further, the obtained carbinol compound is dehydrated in acidic conditions to synthesize a derivative of stilbene, followed by heating it with quinidine hydrochloride as a demethylating agent to form 2-[p-(1,2-diphenyl- 1-butenyl)phenol]. Further, the obtained compound undergoes alkylation with dimethylaminoethylchoride by using sodium ethoxide as a base, which results in the formation of the E and Z isomers of the desired product. Further, the desired tamoxifen compound is extracted through fractional distillation by using a petroleum ester.

Tamoxifen is a drug that belongs to the class of selective estrogen receptor modulators (SERMs). The molecular formula of the compound is C26H29NO, and its molecular weight is 371.5 g/mol. Moreover, the melting point of the compound is 97-98 °C, and its boiling point is 501.18°C. The density of the compound is 1.0630 gm/cm3, and its pka value is 8.71. Additionally, the compound is not soluble in water but gets dissolved in methanol, ethanol, and propylene glycol. The compound exists in the form of a white crystalline solid and is light-sensitive. The compound is administered orally in the form of oral tablets and oral solutions.