Tenofovir Disoproxil Fumarate Production Cost Reports

The report provides a detailed analysis essential for establishing a Tenofovir Disoproxil Fumarate manufacturing plant. It encompasses all critical aspects necessary for Tenofovir Disoproxil Fumarate production, including the cost of Tenofovir Disoproxil Fumarate production, Tenofovir Disoproxil Fumarate plant cost, Tenofovir Disoproxil Fumarate production costs, and the overall Tenofovir Disoproxil Fumarate manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Tenofovir Disoproxil Fumarate production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Tenofovir DF is an FDA-approved antiviral drug that finds huge applications in the pharmaceutical industry. It is widely used as a drug for the treatment of HIV infection in adults and children not less than two years of age. Moreover, the compound is also used as a medication for the treatment of Hepatitis B virus [HBV] infection in adults and pediatric patients 12 years of age and older. Additionally, the compound is also employed in combination treatment for the treatment and prevention of AIDS and chronic hepatitis B infections.

The market for Tenofovir Disoproxil Fumarate is majorly driven by its usage as an anti-HIV agent in the treatment of AIDS/HIV-1 infection, which significantly promotes its demand in the medical and healthcare industry. Moreover, its employment in the treatment of chronic hepatitis B and combination therapy for the treatment and prevention of HIV in high-risk individuals further enhances its demand in the pharmaceutical industry.

Additionally, procurement practices are defined on the basis of several crucial factors, which include the cost and the availability of raw materials (R-propylene carbonate, etc.), medical applications, and regulatory compliance. Generally, technological advancements related to its usage, supplier reliability, sustainability practices, and logistics largely impact industrial Tenofovir Disoproxil Fumarate procurement.

Raw Material for Tenofovir Disoproxil Fumarate Production

According to the Tenofovir Disoproxil Fumarate manufacturing plant project report, the major raw materials for Tenofovir Disoproxil Fumarate production include Adenine and R-Propylene Carbonate.

Manufacturing Process of Tenofovir Disoproxil Fumarate

The extensive Tenofovir Disoproxil Fumarate production cost report consists of the following industrial manufacturing process:

1. Production from Adenine: This method of production is initiated by the reaction of adenine and R-propylene carbonate as initial raw materials to produce R-9-(2-hydroxypropyl)adenine. Further, the obtained R-9-(2-hydroxypropyl)adenine undergoes condensation with diethyl(tosyloxy)methylphosphonate in the presence of magnesium as a catalyst to form R-9[2-(diethyl-phosphonic acid methoxy)propyl]adenine. Then, the obtained product undergoes hydrolysis to give tenofovir, followed by its condensation with chloromethyl isopropyl carbonate under the catalytic action of triethylamine, which results in the formation of tenofovir disoproxil fumarate as the final product.

Tenofovir Disoproxil Fumarate (TDF) or Tenofovir DF is a fumaric acid salt form of tenofovir that serves as a pro-drug. The molar mass of the compound is 635.5 g/mol, and its molecular formula is C23H34N5O14P. The compound is mainly marketed under the brand name Viread. Moreover, the melting point of the compound ranges between 113-115°C and is stored between the temperature range of 2-8°C. The compound appears as a white to beige powder that is slightly soluble in DMSO and methanol. The compound serves as a medication used in combination therapy for the treatment of HIV infection.