Tolbutamide Production Cost Reports

The report provides a detailed analysis essential for establishing a Tolbutamide manufacturing plant. It encompasses all critical aspects necessary for Tolbutamide production, including the cost of Tolbutamide production, Tolbutamide plant cost, Tolbutamide production costs, and the overall Tolbutamide manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Tolbutamide production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Tolbutamide functions as an oral antihyperglycemic agent, primarily utilized to treat type-2 diabetes, especially in individuals whose blood glucose levels cannot be controlled by diet alone. It is a part of the first-generation sulfonylurea group of drugs and works by activating the β cells in the pancreas to secrete insulin, thus reducing the blood glucose levels in individuals with type-2 diabetes mellitus. It is commonly known as Orinase.

The procurement of Tolbutamide is influenced by its application in the pharmaceutical and medical industries as an oral antihyperglycemic drug to manage type-2 diabetes mellitus. As a first-generation sulfonylurea, it functions by stimulating the pancreatic β cells to release insulin, thereby reducing the blood glucose levels. The increasing worldwide incidence of type-2 diabetes boosts the demand for Tolbutamide.

Continuous research that emphasizes its benefits and identifies new therapeutic applications can revive its procurement. Moreover, Tolbutamide has been utilized in numerous clinical applications and trials, enhancing its prominence in the field of diabetes treatment. Conclusively, the industrial Tolbutamide procurement is influenced by its therapeutic applications in the pharmaceutical and medical industries, continuous use in research, its cost-effectiveness, regulatory approvals, logistics and distribution, etc.

Raw Material for Tolbutamide Production

According to the Tolbutamide manufacturing plant project report, the key raw materials used in the production of Tolbutamide include butyl isocyanate - 4-toluenesulfonamide.

Manufacturing Process of Tolbutamide

The extensive Tolbutamide production cost report consists of the following major industrial manufacturing process:

• Production from butyl isocyanate and 4-toluenesulfonamide: The manufacturing process of Tolbutamide begins with reaction of butyl isocyanate and 4-toluenesulfonamide to yield the active pharmaceutical ingredient. After the synthesis, Tolbutamide is purified through processes such as crystallization and extraction and subsequently dried to eliminate any remaining solvents.

Tolbutamide is a white crystalline powder having the molecular formula C12H18N2O3S and a molecular weight of 270.35 g/mol. Its IUPAC name is 1-butyl-3-(4-methylphenyl)sulfonylurea. Its melting point is approximately 128.5-129.5 °C. It dissolves in organic solvents such as ethanol, DMSO, and dimethyl formamide. It is sparingly soluble in aqueous buffers. It is commonly known as Orinase. Tolbutamide is an oral antihyperglycemic drug belonging to the class of first-generation sulfonylureas. It is used in the treatment of type-2 diabetes mellitus by increasing the insulin release and reducing the blood glucose levels.