Tolmetin Production Cost Reports

The report provides a detailed analysis essential for establishing a Tolmetin manufacturing plant. It encompasses all critical aspects necessary for Tolmetin production, including the cost of Tolmetin production, Tolmetin plant cost, Tolmetin production costs, and the overall Tolmetin manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Tolmetin production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Tolmetin is an FDA-approved drug that is widely known for its potent anti-inflammatory properties. The compound is widely used as a non-steroidal drug for the treatment of rheumatoid arthritis and juvenile rheumatoid arthritis. It is often used to relieve the chronic symptoms of osteoarthritis and ankylosing spondylitis. Moreover, it is also used for the treatment and management of various painful conditions, including osteoarthritis and chronic arthritis, due to its strong analgesic and antipyretic activity.

The demand for Tolmetin is predominantly driven due to its key role as a nonselective, nonsteroidal anti-inflammatory drug for relieving pain in rheumatoid arthritis, which notably contributes to its market expansion. Moreover, its usage as an oral steroid-free drug for the treatment and management of various inflammatory body conditions, including osteoarthritis and ankylosing spondylitis, further accentuates its demand in the pharmaceutical industry. Additionally, its application for the treatment of juvenile rheumatoid arthritis due to its minimal side effects remarkably fuels its demand in healthcare industry. In general, factors, including the availability of raw materials (ethyl 2-chloro-2-oxoacetate, etc.), pricing, compliance with healthcare regulations, scientific advancements, and quality standards, greatly influence industrial Tolmetin procurement.

Raw Material for Tolmetin Production

According to the Tolmetin manufacturing plant project report, the major raw materials for Tolmetin production include 1-Methyl-1H-Pyrrole and Ethyl 2-Chloro-2-Oxoacetate and Methyl Carbonochloridate.

Manufacturing Process of Tolmetin

The extensive Tolmetin production cost report consists of the following industrial manufacturing process:

1. Production from 1-Methyl-1H-Pyrrole: This method of production is initiated by the process of electrophilic substitution of 1-methyl-1H-pyrrole with ethyl 2-chloro-2-oxoacetate, followed by hydrolysis in the presence of NaOH to give sodium 2-(1-methyl-1H-pyrrol-2-yl)-2-oxoacetate. Further, the obtained sodium 2-(1-methyl-1H-pyrrol-2-yl)-2-oxoacetate undergoes Wolff-Kishner-Huangmin lon-reduction reaction to synthesize the corresponding acetic acid. Then, the obtained acid compound is reacted with methyl carbonochloridate in ethyl acetate to give corresponding acid anhydride, followed by Friedel-Crafts acylation with 4-methylbenzoyl chloride to give a ketone compound. As the last step, the ketone compound undergoes alcoholysis, followed by hydrolysis, which results in the formation of Tolmetin as the final product.

Tolmetin is a synthetic drug that belongs to the class of pyrroles. The drug is similar in mode of action to the drug indomethacin. The IUPAC name of the compound is 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetic acid. Moreover, the melting point of the compound is 156 °C, and its boiling point is 400.53°C. The density of the compound is 1.1391 gm/cm3, and its solubility in water is 222 mg/L. Additionally, the compound is broadly marketed under the brand name Tolectin, and it is administered in three ways that include orally, rectally, or topically. And, the compound is slightly soluble in chloroform and methanol.