Tolterodine Tartrate Production Cost Reports

The report provides a detailed analysis essential for establishing a Tolterodine tartrate manufacturing plant. It encompasses all critical aspects necessary for Tolterodine tartrate production, including the cost of Tolterodine tartrate production, Tolterodine tartrate plant cost, Tolterodine tartrate production costs, and the overall Tolterodine tartrate manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Tolterodine tartrate production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Tolterodine tartrate is a muscarinic receptor antagonist used to treat overactive bladders (OABs) that cause urinary frequency, urgency, and incontinence. It binds to the M3 muscarinic receptors present in the bladder. This reduces bladder contraction by raising the tone of the internal urethral sphincter and decreasing the tone of the detrusor muscle. It is also used to treat bladder overactivity due to neurological disorders like multiple sclerosis or spinal cord injuries. Thus, it finds its application in the pharmaceutical and medical industries.

The procurement of Tolterodine tartrate is influenced by its application in the pharmaceutical and medical industries to treat overactive bladder symptoms. The need for Tolterodine tartrate is increasing as cases of overactive bladder are on the rise. It witnesses a significant demand from the aging population as they are more likely to be affected by urinary disorders such as overactive bladder. This medication is the gold standard for treating OAB. It is thought to be the third most effective antimuscarinic and has fewer side effects than other options, such as oxybutynin, which increases its demand.

Tolterodine tartrate is more tolerable than other medications of its class. Clinical research has demonstrated that Tolterodine tartrate combined with an alpha-blocker, like tamsulosin, significantly reduces symptoms. Overall, the industrial Tolterodine tartrate procurement is influenced by its application in the pharmaceutical and medical industries to treat overactive bladder symptoms, the increasing cases of OABs, the aging population, fewer side effects, better tolerability, along with research and development, increasing healthcare awareness, and regulatory approvals.

Raw Material for Tolterodine Tartrate Production

According to the Tolterodine tartrate manufacturing plant project report, the key raw materials used in the production of Tolterodine tartrate include cinnamic acid - 4-methyl phenol.

Manufacturing Process of Tolterodine Tartrate

The extensive Tolterodine tartrate production cost report consists of the following major industrial manufacturing process:

• Production from cinnamic acid and 4-methyl phenol: The manufacturing process of Tolterodine tartrate involves several key steps. The first step involves condensation of 4-methyl phenol and cinnamic acid in sulfuric acid to produce lactone. In the next step, the lactone is opened with potassium carbonate while acetone and methanol are refluxed in the presence of methyl iodide to form the appropriate methyl ester. The methyl ester undergoes reduction with lithium aluminum hydride in diethyl ether to produce the corresponding alcohol. The alcohol is then tosylated and the resulting tosyl derivative is then condensed with diisopropylamine in acetonitrile to yield a tertiary amine. The amine is then reacted with boron tribromide in dichloromethane to form a hydroxy compound. In the final step, the hydroxy compound is resoluted with tartaric acid to form Tolterodine tartrate.

Tolterodine tartrate, commercially known as Detrol, is a white to off-white crystalline powder having the molecular formula C26H37NO7 and a molecular weight of 475.6 g/mol. Its water solubility is 0.00534 mg/mL. It has a log P value of 5.39. It dissolves in water and ethanol and is somewhat soluble in methylene chloride. Tolterodine tartrate is a muscarinic receptor antagonist used to treat overactive bladder symptoms.