Vandetanib Production Cost Reports

The report provides a detailed analysis essential for establishing a Vandetanib manufacturing plant. It encompasses all critical aspects necessary for Vandetanib production, including the cost of Vandetanib production, Vandetanib plant cost, Vandetanib production costs, and the overall Vandetanib manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Vandetanib production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Vandetanib is a medication used for treating cancer by blocking proteins that promote tumor growth and the formation of new blood vessels. It works to block important receptors in the development of cancer, thus slowing down or stopping the disease. It is used for the treatment of locally advanced or metastatic medullary thyroid cancer. As a monotherapy, its recommended dose is 300 mg orally once daily until disease progression. Its common side effects are diarrhoea, nausea, fatigue, and rash, followed by hypertension. Also, there has been some emerging preclinical research where vandetanib could have an impact on asthma by having anti-inflammatory properties and suppressing airway hyperresponsiveness.

The market Vandetanib is driven by several key factors. Increasing cases of thyroid cancers among people due to lifestyle factors such as obesity and smoking and diagnosing contributes to its growing demand as an effective medication. New and advanced technology in oncology research and the introduction of new applications and formulations make it a popular product. The market is focusing on mergers, acquisitions, and partnership activities to maintain market presence and competitiveness that further contributes to its demand.

The increasing trend of targeted therapy use in oncology, where most healthcare providers and patients are keen to opt for personalized treatment solutions, makes it a sought-after product. Its increased global availability and growth of online pharmacy solutions enabling increased use of this lifesaving cancer therapy also fuels its demand. Thus, industrial Vandetanib procurement is affected by the increasing cases of thyroid cancers, advancements in oncology research, strategic mergers, and partnerships, inclination towards targeted therapies, and enhanced global availability.

Raw Material for Vandetanib Production

According to the Vandetanib manufacturing plant project report, the key raw materials used in the production of Vandetanib include Quinazoline Derivative-Aniline Compound-Reducing Agents-Reagents.

Manufacturing Process of Vandetanib

The extensive Vandetanib production cost report consists of the following major industrial manufacturing process:

• From Quinazoline Derivative, Aniline Compound, Reducing Agents, and Reagents: The manufacturing of Vandetanib consists of several steps. First, a quinazoline derivative is obtained that is reacted with an aniline compound, forming the core structure of vandetanib. After that, a nitro group is introduced in the structure, followed by its reduction to an amine-forming vandetanib. The crude product is purified by crystallization and chromatography to get pure Vandetanib.

Vandetanib appears as a solid that has a molecular formula of C22H24BrFN4O2 and a molecular weight of 475.4 Da. It is practically insoluble in water, slightly soluble in methanol, and soluble in acetone and dimethyl sulfoxide (DMSO). It is lipophilic in nature, with an XLogP3 value of 4.9. The H-bond donors are seven, the acceptors are one, and number of rotatable bonds is six, and its topological polar surface area is 59.5 Ų. It is generally heat and hydrolysis stable but undergoes some photolytic degradation. All these physical and chemical properties are important to define its pharmacology.