Vardenafil Production Cost Reports

The report provides a detailed analysis essential for establishing a Vardenafil manufacturing plant. It encompasses all critical aspects necessary for Vardenafil production, including the cost of Vardenafil production, Vardenafil plant cost, Vardenafil production costs, and the overall Vardenafil manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Vardenafil production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Vardenafil is a Phosphodiesterase 5 inhibitor used to treat erectile dysfunction. It inhibits the Phosphodiesterase type-5 enzyme, which decreases its function to act. It inhibits the breakdown of cyclic guanosine monophosphate (cGMP), increasing the blood flow to the penis during sexual stimulation. Vardenafil has also been studied for its possible role in the treatment of pulmonary hypertension and premature ejaculation, in addition to erectile dysfunction. Thus, it finds its application in the pharmaceutical and medical industries.

The procurement of Vardenafil is influenced by its application in the pharmaceutical and medical industries as an inhibitor of Phosphodiesterase type-5, used for the treatment of erectile dysfunction. The increasing demand for Vardenafil is affected by the rising cases of erectile dysfunction in recent times. Due to its ability to increase blood flow, it can also be used in the treatment of hypertension and conditions such as premature ejaculation. The drug is present in various forms, such as oral dispersible forms, which makes it easier to intake and increases patient compliance.

Increasing awareness among patients about sexual healthcare also increases the demand for Vardenafil.  Overall, the industrial Vardenafil procurement is affected by its application in the pharmaceutical and medical industries to treat erectile dysfunction, its use in hypertension and premature ejaculation, increasing cases of erectile dysfunction, various forms of the medication, patient compliance, increasing sexual health awareness, technological advancements, cost-effectiveness, along with logistics and distribution, and regulatory approvals.

Raw Material for Vardenafil Production

According to the Vardenafil manufacturing plant project report, the key raw materials used in the production of Vardenafil include 2-hydrozybenzonitrile.

Manufacturing Process of Vardenafil

The extensive Vardenafil production cost report consists of the following major industrial manufacturing process:

• Production with 2-hydrozybenzonitrile: The manufacturing process of Vardenafil involves several key steps. In the first step, 2-hydrozybenzonitrile undergoes alkylation with ethyl bromide to form an intermediate. This intermediate is converted into amidine by reacting with AlMeClNH2. This amidine is treated with hydrazine hydrate to form amidrazone. Simultaneously, D,L-Alanine is N-acylated with butyryl chloride using trimethyl silyl chloride (TMSCl) for in situ protection of the acid group, yielding butyrylalanine. In the next step, butyrylalanine is subjected to a Dakin-West reaction with ethoxy oxalyl chloride in THF, using pyridine as a base and 4-dimethylaminopyridine as a catalyst, resulting in the formation of a mixed acid anhydride. Upon refluxing in ethanol, the mixture of amidrazone and the prepared mixed acid anhydride produced a condensation product. The dehydration-cyclization reaction with POCl3 formed imidazolotriazinone, which is then chlorosulfonated to produce an intermediate which followed by sulfonamide formation yields the desired Vardenafil.

Vardenafil, also known as Levitra, is a colorless solid, having the molecular formula C23H32N6O4S and a molecular weight of 488.6 g/mol. Its melting point is 192°C. Its solubility in water is 0.11 mg/mL (HCl salt). It has an estimated water solubility of 0.325 mg/ml at 25 °C. Its log P value is 1.4. It is a Phosphodiesterase type-5 inhibitor that is used to treat erectile dysfunction by increasing the blood flow. It can also be used to prevent and treat pulmonary hypertension and premature ejaculation.