Venlafaxine Production Cost Reports

The report provides a detailed analysis essential for establishing a Venlafaxine manufacturing plant. It encompasses all critical aspects necessary for Venlafaxine production, including the cost of Venlafaxine production, Venlafaxine plant cost, Venlafaxine production costs, and the overall Venlafaxine manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Venlafaxine production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Venlafaxine is a member of the class of drugs called Serotonin-norepinephrine reuptake inhibitors (SNRIs). It is an antidepressant medication used to treat panic disorder, social anxiety disorder, and major depressive disorder (unipolar). It is also frequently used off-label to treat a variety of illnesses, including premenstrual dysphoric disorder, obsessive-compulsive disorder, fibromyalgia, diabetes, complex pain syndromes, hot flashes, migraine prevention, and attention-deficit disorder. It can be utilized alone or with other drugs, for combination therapy.

The procurement of Venlafaxine is influenced by its application in the pharmaceutical and medical industries as an antidepressant drug used to treat major depressive disorders. The need for Venlafaxine is increasing as cases of depressive disorders are on the rise. In addition to being used to treat depressive disorders, it is also effective in a variety of illnesses, including premenstrual dysphoric disorder, obsessive-compulsive disorder, fibromyalgia, diabetes, complex pain syndromes, hot flashes, migraine prevention, and attention-deficit disorder, thus increasing its demand. It witnesses a significant demand from the aging population as they are more likely to be affected by mental health problems.

Compared to norepinephrine reuptake, Venlafaxine is a more powerful serotonin reuptake inhibitor. It is also known that Venlafaxine lowers neuroinflammation.  Overall, the industrial Venlafaxine procurement is influenced by its application in the pharmaceutical and medical industries as an antidepressant medication to treat panic disorder, social anxiety disorder, and major depressive disorder, the rising cases of mental disorders, the aging population, its wide range of applications, off-label uses, better mechanism of action, along with cost-effectiveness, increasing awareness among individuals about mental health, technological advancements, research and development, and regulatory approvals.

Raw Material for Venlafaxine Production

According to the Venlafaxine manufacturing plant project report, the key raw material used in the production of Venlafaxine includes 4-methoxyphenyl acetonitrile.

Manufacturing Process of Venlafaxine

The extensive Venlafaxine production cost report consists of the following major industrial manufacturing process:

• Production from 4-methoxyphenyl acetonitrile: The manufacturing process of Venlafaxine involves several steps. To create (RS)-1-[cyano-(4-methoxyphenyl)methyl]cyclohexanol, 4-methoxyphenyl acetonitrile is first combined with cyclohexanone in the presence of a strong base (lithium diisopropylamide or butyl lithium). After that, this intermediate is catalytically hydrogenated on alumina using rhodium to form an amine intermediate. The final step is the Eschweiler-Clarke reductive amination process, which dimethylates the amine and produces Venlafaxine.

Venlafaxine, commercially known as Effexor, appears as a white to off-white crystalline solid, having the molecular formula C17H27NO2 and a molecular weight of 277.4 g/mol. It has a melting point in the range of 102-104 °C. Its partition coefficient is around 0.43, with a log P value of 2.68. The value of its dissociation constant, pKa, is 9.5. It is soluble in water, ethanol, methanol, and chloroform but is nearly insoluble in common organic solvents. It is a serotonin-norepinephrine reuptake inhibitor utilized to treat a variety of mental disorders.