Voriconazole Production Cost Reports
Healthcare
The report provides a detailed analysis essential for establishing a Voriconazole manufacturing plant. It encompasses all critical aspects necessary for Voriconazole production, including the cost of Voriconazole production, Voriconazole plant cost, Voriconazole production costs, and the overall Voriconazole manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Voriconazole production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.
Voriconazole is a potent antifungal medication with major applications in the pharmaceutical and medical fields. It is widely used as an oral drug for the treatment of fungal infections caused by various organisms. It is also utilized as a medication to treat serious fungal infections, such as esophageal candidiasis and invasive aspergillosis, for both adults and children above 2 years of age. It also finds its application in the form of an injection for the treatment of certain endemic fungal infections such as coccidioidomycosis and histoplasmosis.
The primary factor that drives the market for Voriconazole is its demand as an oral drug in the first-line treatment for various serious fungal infections. Its utilization as a first-line treatment for invasive aspergillosis, a life-threatening fungal infection that affects immunocompromised individuals, significantly promotes its demand in the pharmaceutical industry. Its application as a medication for the treatment of serious fungal infections in children and adults largely contributes to its demand in the medical and pharmaceutical industries.
Changes in the availability and cost of raw materials necessary for synthesizing Voriconazole largely impact its production and industrial Voriconazole procurement. Changes in medical guidelines, healthcare practices, and patient preferences directly affect the demand and procurement strategies for Voriconazole. International trade policies, tariffs, and geopolitical issues also affect the global supply chain for pharmaceuticals, which further impacts the cost and availability of Voriconazole.
Raw Material for Voriconazole Production
According to the Voriconazole manufacturing plant project report, the major raw material for Voriconazole production includes 5-Fluorouracil.
Manufacturing Process of Voriconazole
The extensive Voriconazole production cost report consists of the following industrial manufacturing process:
- Production via Chemical Synthesis: The synthesis of Voriconazole begins with the chlorination of 5-fluorouracil in both the 2- and 4- positions by using a mixture of phosphorus oxychloride and N,N-dimethylaniline at 95 degree Celsius to form 2,4-dichloro-5-fluoropyrimidine. This compound reacts with ethyl magnesium bromide and is further oxidized to yield 2,4-dichloro-6-ethyl-5-fluoropyrimidine. Then, the selective displacement of the chloro group results in the formation of 2-chloro-6-ethyl-5-fluoro-4(3H)-pyrimidine, which is isolated as its ammonia salt. Further, the dechlorination of the obtained ammonia salt produces 4-fluoro-6-ethyl-5-fluoropyrimidine. An alternative route to this compound involves fluorination of methyl 3-oxopentanoate to methyl 2-fluoro-3-oxopentanoate, followed by cyclization. The synthesis continues with chlorination to form 4-chloro-6-methyl-5-fluoropyrimidine, followed by bromination to create 4-bromo-6-methyl-5-fluoropyrimidine and a Reformatsky reaction with a ketone intermediate from the Diflucan synthesis. This yields a mixture of diastereomers, with the desired product as the major component. Finally, it undergoes dichlorination, which produces racemic voriconazole. As the last step, the resultant racemic Voriconazole is resolved into its optically pure form using (1R)-10-camphorsulfonic acid to obtain Voriconazole with high purity and yield as the final product.
Voriconazole is an antifungal compound with distinct physical and chemical properties. It appears as a white to almost white powder or crystalline solid. The molecular weight of the compound is 349.3105 g/mol. The melting point of the compound ranges between 130-134 degree Celsius. It is poorly soluble in water but soluble in methanol. Its chemical formula is C16H14F3N5O, which contains a triazole ring, a pyrimidine ring, and a difluorophenyl group. Voriconazole is generally stable under normal conditions. These characteristics contribute to voriconazole's efficacy as an antifungal agent and influence its behavior in the body.
Product Details
| Particulars | Details |
|---|---|
| Product Name | Voriconazole |
| Scope | Manufacturing Process: Process Flow, Material Flow, Material Balance Raw Material and Product Specifications: Raw Material Consumption, Product and Co-product Generation Land and Site Cost: Offsites/Civil Works, Equipment Cost, Auxiliary Equipment Costs, Contingency, Engineering and Consulting Charges, Working Capital Variable Cost: Raw Material, Utilities, Other Variable Costs Fixed Cost: Labor Requirements and Wages, Overhead Expenses, Maintenance Charges, Other Fixed Costs Financing Costs: Interest on Working Capital, Interest on Loans Other Costs: Depreciation Charges, General Sales and Admin Cost |
| Currency | US$ (Data can also be provided in the local currency) |
| Pricing and Purchase Options | Basic: US$ 2499 Premium: US$ 3499 Enterprise: US$ 4799 |
| Customization Scope | The report can be customized as per the requirement of the customer |
| Post-Sale Analysts Report | 10-12 weeks of post-purchase analyst support after report delivery for any queries from the deliverable |
| Delivery Format | PDF and Excel format through email (editable version in PPT/Word format of the report can be also provided on special request) |
How does our Voriconazole Production Cost Report Provide Exhaustive Data and Extensive Insights?
At Procurement Resource, we not only focus on optimizing the should cost of production for Voriconazole but also provide our clients with extensive intel and rigorous information on every aspect of the production process. By utilizing a comprehensive cost model, we help you break down expenses related to raw materials, labor, and technology, offering clear pathways to savings. We also assist in evaluating the capital expenditure (CAPEX) and operating expenses (OPEX), which are often measured as cost per unit of production, such as USD/MT, ensuring that your financial planning is aligned with industry benchmarks.
We offer valuable insights on the top technology providers, in-depth supplier database, and best manufacturers, helping you make informed decisions to improve efficiency. Additionally, we design the most feasible layout for your production needs, ensuring the entire process runs smoothly. By minimizing the cash cost of production, we ensure that you stay competitive while securing long-term profitability in the growing Voriconazole market. Partnering with Procurement Resource guarantees that every aspect of your production is cost-efficient, advanced, and tailored to your specific requirements.
Key Questions Answered in This Report
- What are the key requirements for setting up a Voriconazole manufacturing plant?
- How is Voriconazole manufactured?
- What is the process flow involved in producing Voriconazole?
- What are the raw material requirements and costs for producing Voriconazole?
- What is the total size of land required for setting up a Voriconazole manufacturing plant?
- What are the construction requirements for setting up a Voriconazole manufacturing plant?
- What are the machinery requirements for producing Voriconazole?
- What are the utility requirements and costs for producing Voriconazole?
- What are the manpower requirements for producing Voriconazole?
- What are the average salaries/wages of manpower working in a Voriconazole manufacturing plant?
- What are the packaging requirements and associated costs for Voriconazole?
- What are the transportation requirements and associated costs for Voriconazole?
- What are the capital costs for setting up a Voriconazole manufacturing plant?
- What are the operating costs for setting up a Voriconazole manufacturing plant?
- What should be the price of Voriconazole?
- What will be the income and expenditures for a Voriconazole manufacturing plant?
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