Zonisamide Production Cost Reports

The report provides a detailed analysis essential for establishing a Zonisamide manufacturing plant. It encompasses all critical aspects necessary for Zonisamide production, including the cost of Zonisamide production, Zonisamide plant cost, Zonisamide production costs, and the overall Zonisamide manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Zonisamide production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Zonisamide is an anticonvulsant drug used as an adjuvant treatment for partial seizures in adults. It is also recognized for its use to treat myoclonic, generalized tonic-clonic seizures, infantile spasms, and mixed forms of Lennox-Gastaut syndrome seizures in adults. It is efficient in preventing migraines. It has also demonstrated beneficial results in reducing tardive dyskinesia symptoms. It works by regulating the electric currents that cause seizures by acting on the calcium and sodium channels in the brain. Thus, it finds its wide range of applications in the pharmaceutical and medical industries.

The procurement of Zonisamide in influenced by its application in the pharmaceutical and medical industries as an antiepileptic drug to treat seizures in adults. The need for Zonisamide is increasing as cases of epilepsy are on the rise. In addition to being used to treat epilepsy, it is also effective in treating neuropathic pain, manic episodes, and Parkinson’s disease symptoms. It is also capable of initiating neuroprotective processes and decreases lipid peroxidation and ischemia-induced memory impairment by inhibiting nitric oxide synthase.

This ability of the drug increases its demand. It witnesses a significant demand from the aging population as they are more likely to be affected by neurological disorders such as epilepsy. It also serves as a substitute medication for individuals who do not respond to well-established antiepileptic medications. Overall, the industrial Zonisamide procurement is influenced by its application in the pharmaceutical and medical industries as an anticonvulsant or antiepileptic medication used to treat a variety of seizures, increasing cases of epileptic diseases, the aging population, its use as a substitute medication, along with technological advancements, increasing healthcare awareness among patients, cost-effectiveness, and regulatory approvals.

Raw Material for Zonisamide Production

According to the Zonisamide manufacturing plant project report, the key raw material used in the production of Zonisamide include 3-bromomethyl-1,2-benzisoxazole.

Manufacturing Process of Zonisamide

The extensive Zonisamide production cost report consists of the following major industrial manufacturing process:

• Production from 3-bromomethyl-1,2-benzisoxazole: The manufacturing process of Zonisamide involves several key steps. In the first step, a solution of 3-bromomethyl-1,2-benzisoxazole in methanol is reacted with a solution of sodium sulfite in water. The mixture is subjected to ambient temperature and pressure, and then the liquid is concentrated to produce sodium 1,2-benzisoxazole-3-methanesulfonate. This intermediate is heated with phosphorus oxychloride under reflux to form 1,2-benzisoxazole-3-methanesulfonyl chloride in ethyl acetate by distillation and filtration. In the next step, the sulfonyl chloride solution is finally left to stand at ambient temperature after saturating it with ammonia gas. In the final step, the intermediate is treated with ethyl acetate to form Zonisamide.

Zonisamide, commercially known as Zonegran, has a molecular formula C8H8N2O3S and a molecular weight of 212.23 g/mol. It is tasteless and odorless. Its melting point is 161-163 °C. Its solubility is 0.8mg/mL. It is sparingly soluble in chloroform and n-hexane and dissolves in methanol, ethanol, ethyl acetate, and acetic acid. Its log P value is 0.5. The value of its dissociation constant, pKa, is 10.2. Zonisamide is a member of the class of drugs called sulfonamides. It is an anticonvulsant drug used to treat a variety of seizures in epileptic patients.