Phenylbutazone Manufacturing Plant Project Report: Key Insights and Outline

Phenylbutazone Manufacturing Plant Project Report thoroughly focuses on every detail that encompasses the cost of manufacturing. Our extensive cost model meticulously covers breaking down expenses around raw materials, labour, technology, and manufacturing expenses. This enables precise cost structure optimization and helps in identifying effective strategies to reduce the overall cash cost of manufacturing.

Phenylbutazone is a non-steroidal anti-inflammatory drug (NSAID) used mainly for pain relief and reducing inflammation. It is widely used as a drug to manage pain, inflammation, and fever associated with musculoskeletal disorders, such as arthritis, laminitis, tendinitis, and bursitis in horses. It also finds its application in the manufacturing of certain NSAID formulations for the treatment of pain and inflammation in horses and livestock. It is also used as a hepatotoxin in laboratory research, particularly in toxicology studies and screening assays involving animal models.
 

Top 10 Manufacturers of Phenylbutazone

• Century Pharmaceuticals Limited
• Nantong Jinghua Pharmaceutical
• Hengdian Group
• Arshine Pharmaceutical Co., Limited
• Aurora Industry Co., Ltd
• AMGIS Lifescience Ltd.
• Jai Radhe Sales
• HRV Global Life Sciences
• Qingdao Qingmei Biotech
• Reine Lifescience
   

Feedstock for Phenylbutazone

The feedstock involved in the production of Phenylbutazone is Diethyl-n-butylmalonate and 1,2-Diphenylhydrazine. The synthesis of diethyl-n-butylmalonate involves the use of diethyl malonate and n-butyl chloride. The availability and price variations of these precursor chemicals play a crucial role in dictating the production and sourcing strategies for diethyl-n-butylmalonate. Supply chain disruptions or shortages in these raw materials also significantly impact the production of diethyl-n-butylmalonate. Compliance with strict regulations related to safety, environmental impact, and transport can also affect production costs and influence sourcing decisions for diethyl-n-butylmalonate. The demand from end-use industries such as pharmaceuticals and agrochemicals also serves as a major factor in affecting the market price and sourcing decisions for diethyl-n-butyl malonate.

1,2-Diphenylhydrazine is another raw material used in the manufacturing of phenylbutazone. 1,2-Diphenylhydrazine is subject to strict regulatory supervision due to its potential health hazards, including its possible carcinogenicity. Regulations such as REACH in Europe and TSCA in the USA significantly impact how it can be produced, handled, and transported. Compliance with these regulations can greatly affect the availability, costs, and sourcing strategies for 1,2-Diphenylhydrazine. The production of 1,2-Diphenylhydrazine requires specific precursors such as aniline and hydrazine. The availability and price of these raw materials can significantly influence the production costs and availability of 1,2-Diphenylhydrazine. The synthesis of 1,2-Diphenylhydrazine requires specialized equipment and expertise due to the handling and safety measures needed for its reactive raw materials. Manufacturers with better technology can make products that are purer and have higher yields, which further influence sourcing decisions.
 

Market Drivers for Phenylbutazone

The market for Phenylbutazone is predominantly led by its demand as a veterinary medicine for the treatment of pain and inflammation in animals, particularly horses. Its utilization as a nonsteroidal anti-inflammatory drug (NSAID) for the treatment of musculoskeletal disorders in horses largely promotes its demand in the animal health or veterinary pharmaceuticals industry. Its application in the production of drugs to manage inflammation, pain, and fever associated with tendinitis and other musculoskeletal disorders further enhances its demand in the veterinary medicine industry. Its usage as a chemical standard in analytical assays and as a hepatotoxin in toxicology research also contributes to its demand in the Research & development industry.

Phenylbutazone is strictly regulated in many countries, especially because it is banned for use in animals raised for human consumption due to concerns about its potential side effects. Changes in regulations in different countries significantly affect the production and procurement processes for phenylbutazone. Adherence to these regulations is important to avoid legal penalties and keep access to the market. Phenylbutazone is used in veterinary medicine, particularly for horses. Therefore, the demand from this sector drives production and procurement strategies for phenylbutazone. Fluctuations in the equine industry, such as increased horse breeding or racing activities, also directly impact its demand, which further affects industrial Phenylbutazone procurement. The environmental impact of pharmaceutical manufacturing and ethical concerns related to animal welfare can also influence procurement decisions.

The capital expenditures (CAPEX) for manufacturing Phenylbutazone involve several large investments necessary to establish and equip a production facility. Expenses under CAPEX include buying land and building the manufacturing plant, which must be designed to handle chemical processing safely. It also covers the cost of purchasing specialized chemical reactors and mixers, which are critical for synthesizing Phenylbutazone. Other essential equipment includes a Jacketed Glass-Lined Reactor, Vacuum Distillation System, V-Shaped Blender, Pneumatic High Vortex Apparatus, Decanter Centrifuge, Rotary Drum Precoat Filter, Tray Dryer, and Automatic Drum Filling Machine. Moreover, buying HPLC, Melting Point Apparatus, Stainless Steel Storage Tanks, and PLC/DCS Automation is also included in CAPEX. Operating expenses (OPEX) for the production of Phenylbutazone cover the day-to-day costs of running the manufacturing operations. The main components of OPEX include the purchase of raw materials and energy costs for heating and powering equipment. Labor costs are also a significant part of OPEX. Maintenance of equipment to ensure operational efficiency and adherence to environmental and safety standards also adds to the ongoing operational expenses.
 

Manufacturing Process

This report comprises a thorough value chain evaluation for Phenylbutazone manufacturing and consists of an in-depth production cost analysis revolving around industrial Phenylbutazone manufacturing.

• Production from Ilaprazole: The feedstock required for this process includes Diethyl-n-butylmalonate and 1,2-Diphenylhydrazine.

Phenylbutazone is synthesized by reacting diethyl-n-butylmalonate with 1,2-diphenylhydrazine in the presence of sodium ethoxide as a base. The reaction mixture is heated to 150°C to facilitate the process of condensation. After completion of the reaction, the mixture is acidified, which induces cyclization and leads to the formation of phenylbutazone as the final product.
 

Properties of Phenylbutazone

Phenylbutazone is a synthetic nonsteroidal anti-inflammatory drug (NSAID) that appears as an odorless, white, or off-white crystalline powder with a slightly bitter aftertaste. The molecular formula of the compound is C19H20N2O2, and its molecular weight is 308.37 g/mol. The melting point of the compound is in the range of 104–108 degree Celsius. It is only sparingly soluble in water but dissolves more readily in organic solvents such as acetone, chloroform, and benzene, as well as in alkaline solutions. It is relatively stable at room temperature but can decompose through hydrolysis and oxidation, especially when exposed to water or strong oxidizing agents. The compound has a pKa value of 4.5 and has a density of 1.1591 g/cm³.

Phenylbutazone Manufacturing Plant Report provides you with a detailed assessment of capital investment costs (CAPEX) and operational expenses (OPEX), generally measured as cost per metric ton (USD/MT). This approach ensures that your investment decisions are aligned with the latest industry standards and economic feasibility metrics, enhancing your manufacturing efficiency and financial planning.

Apart from that, this Phenylbutazone manufacturing plant report also covers the leading technology providers that help you plan a robust plan of action related to Phenylbutazone manufacturing plant and its production process(es), and also by helping you with an in-depth supplier database. This report provides exclusive insights into the best manufacturing practices for Phenylbutazone and technology implementation costs. This report also covers operational cash flow, fixed and variable costs, and detailed break-even point analysis, ensuring that your manufacturing process is not only efficient but also economically viable in the competitive market landscape.

In addition to operational insights, the Phenylbutazone manufacturing plant report also comprehensively focuses on lifecycle cost analysis, maintenance costs, and energy consumption costs, which are critical for maintaining long-term sustainability and profitability. Our manufacturing cost analysis extends to include regulatory compliance costs, inventory holding costs, and logistics and distribution costs, providing a holistic view of the potential expenses and savings.

We at Procurement Resource ensure that this report is not only cost-efficient, environmentally sustainable, and aligned with the latest technological advancements but also that you are equipped with all necessary tools to optimize supply chain operations, manage risks effectively, and achieve superior market positioning for Phenylbutazone.
 

Key Insights and Report Highlights

Key Questions Covered in our Phenylbutazone Manufacturing Plant Report

• How can the cost of producing Phenylbutazone be minimized, cash costs reduced, and manufacturing expenses managed efficiently to maximize overall efficiency?
• What are the initial investment and capital expenditure requirements for setting up a Phenylbutazone manufacturing plant, and how do these investments affect economic feasibility and ROI?
• How do we select and integrate technology providers to optimize the production process of Phenylbutazone, and what are the associated implementation costs?
• How can operational cash flow be managed, and what strategies are recommended to balance fixed and variable costs during the operational phase of Phenylbutazone manufacturing?
• How do market price fluctuations impact the profitability and cost per metric ton (USD/MT) for Phenylbutazone, and what pricing strategy adjustments are necessary?
• What are the lifecycle costs and break-even points for Phenylbutazone manufacturing, and which production efficiency metrics are critical for success?
• What strategies are in place to optimize the supply chain and manage inventory, ensuring regulatory compliance and minimizing energy consumption costs?
• How can labor efficiency be optimized, and what measures are in place to enhance quality control and minimize material waste?
• What are the logistics and distribution costs, what financial and environmental risks are associated with entering new markets, and how can these be mitigated?
• What are the costs and benefits associated with technology upgrades, modernization, and protecting intellectual property in Phenylbutazone manufacturing?
• What types of insurance are required, and what are the comprehensive risk mitigation costs for Phenylbutazone manufacturing?