Gabapentin Production By Hofmann Rearrangement Reaction
Production Cost Report | Healthcare
Details: Germany - based plant Q2 2024 | From $ USD
This report entails the detailed cost evaluation of gabapentin production by Hofmann rearrangement reaction. The Hofmann rearrangement reaction is a process that converts the primary amide to a primary amine with fewer carbon atoms. In this process, 1,1-cyclohexanediacetic acid monoamide (CAM) undergoes Hofmann rearrangement reaction in the presence of a catalyst (such as phenyl iodosyl bis(trifluoroacetate) or PIFA), that leads to an exothermic reaction in a batch reactor, yielding 1-(aminomethyl)cyclohexaneacetic acid or gabapentin as the final product.
Top Producers of Gabapentin
- Glenmark Pharmaceuticals Limited
- Zydus Pharmaceuticals, Inc.
- Ascend Laboratories, LLC
- Sun Pharmaceutical Industries Ltd.
- Teva Pharmaceutical Industries Ltd.
Feedstock for Gabapentin
Gabapentin is a chemical compound prepared by using 1,1-cyclohexanediacetic acid monoamide (CAM) as one of the major feedstocks. The procurement of gabapentin is chiefly determined by factors including the variations in its production cost and market prices, along with the stability in the supply chain, trading, and transportation activities etc. Moreover, other factors such as the availability of its raw materials (including cyclohexane, ammonia, acetic acid, etc., for 1,1-cyclohexanediacetic acid monoamide (CAM) production), as well as the demand observed for gabapentin (as a pharmaceutical compound), in pharmaceutical and healthcare sectors are also crucial for its procurement around the globe. Similarly, the complex sociopolitical factors and governmental policies also impact its overall procurement.
The project economic analysis provided in the report discusses a Germany-based plant:
- Manufacturing Process
- Process Flow
- Material Flow
- Material Balance
- Raw Material and Product's Specifications
- Raw Material Consumption
- Product and Co-Product Generation
- Capital Investment
- Land and Site Cost
- Offsites/Civil Works
- Equipment Cost
- Auxiliary Equipment Cost
- Contingency
- Engineering and Consulting Charges
- Working Capital
- Variable Cost
- Raw Material
- Utilities
- Fixed Cost
- Labor Requirement & Wages
- Overhead Expenses
- Maintenance Charges
- Financing Costs
- Interest on Working Capital
- Interest on Loans
- Depreciation Charges
- General Sales and Admin Costs
- Production Cost Summary
Report Content
Key Process Information
Evaluation of significant technical parameters along with process descriptions such as:
- Consumption of Raw Material
- Product Creation
- Block Flow Diagram
- Description of the Manufacturing Facility
Utilities Consumption
Evaluation of utilities consumed during the entire process based on:
- Consumption per unit of product generated
- Utility cost split and share of each utility in the total cost
Process Flow Diagram
Representation of various operations involved including:
- Step-wise process
- Utility consumption in each operation
Capital Cost Analysis
In-depth analysis of costs involved in setting up a new manufacturing unit, including:
- Cost of Building a Process Unit
- Cost of Setting Up the Infrastructure
- Working Capital
- Commissioning & Start-Up of the Plant
Implementation Schedule
Time frame of the project design, which includes:
- Plant Start-Up
- Plant Construction
- Engineering Fundamentals
- Raw Material Procurement
Construction Cost Details
Detailed analysis of costs involved in the operation of various functional units in the process unit and infrastructure.
Operating Cost Analysis
Evaluation of costs associated with the production of the final product, namely:
- Procurement of Raw Materials
- Consumption of Utilities
- Fixed Costs
- Depreciation
Economic Analysis
Analysis of the way in which process economics are impacted by plant capacity.
- Construction Cost
- Working Capital
- Fixed and Variable Operating Costs
- Corporate Overhead
- Depreciation
Customized Analyses
Detailed cost estimates of any industrial plant depending on your requirements, including plant capacity and location as per the need.
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