Dipyridamole Production Cost Reports

The report provides a detailed analysis essential for establishing a Dipyridamole manufacturing plant. It encompasses all critical aspects necessary for Dipyridamole production, including the cost of Dipyridamole production, Dipyridamole plant cost, Dipyridamole production costs, and the overall Dipyridamole manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Dipyridamole production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Dipyridamole is a medication that finds its application in the pharmaceutical, medical, and healthcare sectors. It is an important drug that helps in the vasodilation of the blood vessels and ensures smooth heart functioning. It works as a platelet inhibitor and is considered an antithrombotic agent, which can be used to inhibit blood clots. It combines with adenosine, present in the body, to induce vasodilation and improve tissue perfusion. It reduces the risk of complications caused after a heart valve replacement. Also, it is used in combination with aspirin and serves as an antiplatelet drug that works by keeping blood flowing to the brain, preventing the formation of blood clots, and avoiding the situation of ischemic stroke in the brain.

Industrial Dipyridamole procurement is influenced by the demand for Dipyridamole as an antiplatelet drug or a vasodilator in the pharmaceutical and medical industries. Its usage as a vasodilator helps in preventing blood clots in the heart. Its application as a medication for vasodilation ensures smooth heart functioning, preventing strokes caused due to blood clots, driving its demand in the market. A rise in the aging population with heart-related conditions further fuels its demand. Increasing awareness and improved diagnostic techniques make detection for earlier treatment easier, which further adds to its demand. Also, the development of new formulations and combination therapies expands its applications along with better healthcare infrastructure in developing regions, further contributing to its overall procurement.

Raw Material for Dipyridamole Production

According to the Dipyridamole manufacturing plant project report, the key raw materials used in the production of Dipyridamole include 2,4-Dihydroxy-6-methylpyrimidine-Piperidine-Diethanolamine.

Manufacturing Process of Dipyridamole

The extensive Dipyridamole production cost report consists of the following major industrial manufacturing process:

• Production From 2,4-Dihydroxy-6-methylpyrimidine, Piperidine, and Diethanolamine: The production of Dipyridamole involves a multi-step process.  First, nitration of 2,4-dihydroxy-6-methylpyrimidine takes place, forming 5-nitroorotic acid. This compound is then reduced to yield 5-aminoorotic acid. After that, 5-aminoorotic acid is reacted with either urea or potassium cyanide, forming an intermediate. This intermediate goes through a reaction with a mixture of phosphorus oxychloride and phosphorus pentachloride, forming an intermediate compound. This intermediate is treated with piperidine, followed by its reaction with diethanolamine to obtain Dipyridamole as the final product.

Dipyridamole appears as a yellow powder and has a molecular formula of C24H40N8O4 with a molecular weight of 504.626 g/mol. It has a melting point in the range of 165-166 °C with a boiling point of 593.96 °C. Its density value is 1.2046 g/cm³ with a refractive index of around 1.6910. It is slightly soluble in water but dissolves in DMSO, Chloroform, methanol, and dilute acids. Similarly, it is sparingly soluble in aqueous buffers along with some chemical solvents such as dimethyl sulfoxide and ethanol. It possesses vasodilatory and antiplatelet properties, which makes it beneficial for a smooth heart function.