Itraconazole Production Cost Reports

The report provides a detailed analysis essential for establishing an Itraconazole manufacturing plant. It encompasses all critical aspects necessary for Itraconazole production, including the cost of Itraconazole production, Itraconazole plant cost, Itraconazole production costs, and the overall Itraconazole manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating an Itraconazole production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Itraconazole is an antifungal agent primarily used to treat various fungal infections. It finds its major application in the pharmaceutical and healthcare industry. It has a fungal enzyme necessary for ergosterol synthesis, a mycosterol found in the cell membrane of fungi. Thereby disrupting fungal cell membrane integrity. It is used in the treatment of fungal infections such as ringworm, nail infections, etc. It is utilized in the healthcare industry as a prophylactic medicine in immunocompromised individuals. It is useful in treating fungal diseases like onychomycosis and seborrheic dermatitis. It is also used as a prophylactic treatment in immunosuppressed patients suffering from HIV or undergoing chemotherapy. It is widely prescribed in the healthcare industry for treating various fungal infections in patients.

Industrial Itraconazole procurement is influenced by its usage in various healthcare settings, including hospitals, pharmacies, and clinics. The increasing prevalence of fungal infections globally impacts its demand. The growing market demand for Itraconazole due to efforts to reduce its costs further makes an important step in strategizing its procurement. It is also available in various formulations, serving a pivotal role in serving various patient needs. It is used in pharmaceutical industries for conducting research and development activities aimed at enhancing its formulations. Itraconazole’s diverse applications, extending from research and development to manufacturing to distribution, contribute significantly to its market growth.

Raw Material for Itraconazole Production

According to the Itraconazole manufacturing plant project report, the key raw materials used in the production of Itraconazole include Bromomethyl Dichlorophenyl Dioxalane Benzoate-(1H-1,2,4-Triazole)-Dimethyl Formamide.

Manufacturing Process of Itraconazole

The extensive Itraconazole production cost report consists of the following major industrial manufacturing process:

• From Bromomethyl Dichlorophenyl Dioxalane Benzoate, 1H-1,2,4-Triazole, and Dimethyl Formamide: The production of Itraconazole involves a multi-step synthesis process. First, bromomethyl dichlorophenyl dioxalane benzoate is reacted with 1H-1,2,4-triazole in a reactor with sodium hydroxide solution. This mixture is heated and then cooled before adding potassium carbonate to neutralize the reaction. After stirring and filtering to remove insoluble materials, dimethyl formamide (DMF) is distilled to concentrate the product. After that, water and toluene are added to get intermediate compounds that further react to form Itraconazole as the final product. After that, Itraconazole is isolated and purified using solvents such as methanol or acetone.

Itraconazole is a white to slightly yellowish color with a molecular formula of C35H38Cl2N8O4 and a molecular weight of around 705.6 g/mol. It is often odorless or with a faint characteristic odor. Its melting point is in the range 165-166 °C, and its boiling point is around 850 °C. It has a density of 1.27 g/cm³ and has a complex molecular structure with various functional groups such as nitrogen, chlorides, and oxygen-containing groups. It is rapidly absorbed after oral administration. All these physical and chemical properties contribute to its effectiveness in treating a variety of fungal diseases as well as influencing its pharmaceutical formulation.