Metolazone Production Cost Reports

The report provides a detailed analysis essential for establishing a Metolazone manufacturing plant. It encompasses all critical aspects necessary for Metolazone production, including the cost of Metolazone production, Metolazone plant cost, Metolazone production costs, and the overall Metolazone manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Metolazone production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Metolazone is a diuretic medication that is used in the pharmaceutical and healthcare industries. It works by lowering blood pressure and reducing fluid retention by preventing sodium reabsorption in the kidneys, leading to increased urine production. It helps in treating fluid retention, caused by congestive heart failure or kidney conditions and is effective in patients with reduced kidney function.  It is used in combination with other medicines to treat conditions of hypertension and related complications. It reduces the risk of heart failure due to high blood pressure and makes sure that the heart functions properly. Also, it is used for treating edema related to kidney disease and liver cirrhosis.

The market for Metolazone is governed by its growing demand in the pharmaceutical and healthcare sectors. Its utilization in the production of drugs that are taken to treat heart and kidney conditions boosts its demand in the pharmaceutical industry. Its effectiveness, when combined with other pharmaceutical medications to treat hypertension, expands its demand in the healthcare sector. Growing cases of edema and hypertension also contribute to its growing demand as it works effectively for these complications.

The development in pharmaceutical research leads to better formulations and drug-delivery mechanisms that improve its efficiency and demand. Investments in healthcare provide better access to medications that affect industrial Metolazone procurement globally. Also, technological improvements make Metolazone more available and affordable, contributing to its overall demand.

Raw Material for Metolazone Production

According to the Metolazone manufacturing plant project report, the key raw materials used in the production of Metolazone include (5-Chloro-2-Methylaniline)-Ethyl Chloroformate-Chlorosulfonic Acid-(o-Toluidine)-Dimethylacetal Acetic Acid.

Manufacturing Process of Metolazone

The extensive Metolazone production cost report consists of the following major industrial manufacturing process:

1. Production From 5-Chloro-2-Methylaniline, Ethyl Chloroformate, Chlorosulfonic Acid, o-Toluidine, and Dimethylacetal Acetic Acid: The production of Metolazone involves a multi-step process. First, 5-chloro-2-methylaniline reacts with ethyl chloroformate, forming 5-chloro-N-ethoxycarbonyl-2-methylaniline as an intermediate. This intermediate is then reacted with a mixture of chlorosulfonic acid and ammonia to obtain 4-sulfonamido-5-chloro-N-ethoxycarbonyl-2-methylaniline. This sulfonamido compound goes through oxidation using potassium permanganate to form an intermediate. This intermediate is subsequently treated with thionyl chloride and reacted with o-toluidine, leading to the formation of a benzamide. Finally, this benzamide is reacted with dimethylacetal acetic acid forming Metolazone.

Metolazone is a pharmaceutical medication with a molecular formula of C16H16ClN3O3S and a molecular weight of 365.8 g/mol. It is a crystalline solid and has no odor or taste. Its melting point is in the range of 256°C to 260 °C. It is moderately soluble in water and dissolves in different chemical solvents, including alcohols. Similarly, it is soluble in DMSO and dimethyl formamide DMF and sparingly soluble in aqueous buffer solutions. It is a light-sensitive chemical solid that remains stable under standard conditions. However, it decomposes when heated at an elevated temperature and releases irritating fumes, nitrogen oxide, hydrogen chloride, and carbon monoxide into the air.